FASLG and atherosclerosis: During atherosclerosis, lysosome ASM-dependent formation of ceramide-enriched lipid macrodomains in ECs contributes to FasL-induced impairment of the vasodilator response (46, 47) and muscarinic-1 receptor-mediated coronary artery constriction (48), which are both major aggravating factors leading to subsequent atherosclerosis.