SMPD1 and Niemann-Pick disease: Our recent study linked the ASM-MR redox signaling with endothelial NLRP3 inflammasome activation, which was demonstrated by the fact that deficiency of the Smpd1 gene inhibited the activation of endothelial NLRP3 inflammasomes and neointimal lesion formation in a mouse model of Niemann-Pick disease using Smpd1 gene global knockout mice (24).