MAPT and tauopathy: To this aim, we used a previously reported hiPSC tauopathy model, consisting of two different hiPSCs lines with distinct mutations in the microtubule-associated protein tau (MAPT) gene, causing hereditary forms of frontotemporal lobar degeneration (FTLD)-tau (MAPTN279K [exon 10] and MAPTV337M [exon 12]), one wild-type, age-matched control (CTRL1), and one isogenic control of the N279K-mutant hiPSC line (CTRL2) (28, 29).