Mass spectrometry of MGL lysates identified proteins involved in key microglia cell processes, including immune response, oxidative stress response, and IFN-γ, IL-1, and TGF-β signaling, and proteins associated with disease-related microglia responses, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, thus confirming MGL functionality (SI Appendix, Fig. S7 A and B). Here, IFNG is linked to early-onset autosomal dominant Alzheimer disease.