At enrollment, all study participants were negative for COVID-19 diagnosis using qPCR tests whenever participants had any symptoms of SARS-CoV-2 infection and by longitudinal monitoring of anti-spike protein IgG serology [12], although we recognize it remains possible that potential prior exposure cannot be completely ruled out despite negative qPCR or seronegativity [31]. The gene discussed is CHMP5; the disease is COVID-19.