(2) After vaccination of participants with a prior confirmed SARS-CoV-2 infection, IFN-γ, IL2, and IFN-γ+IL2 responses were significantly higher than vaccinated participants without previous infection and were more broadly directed to the S glycoprotein S1 and S2 subunits, as well as N and M protein subpools. The gene discussed is ART4; the disease is infection.