However, Abs398 and Abs575 were 27% and 31% higher in obese vs. non-obese T2D patients, respectively (OR = 4.8; p = 0.041 and OR = 4.6; p = 0.017) (Fig 4B and 4F; Table 2), and positively associated to the total daily dose of insulin (r = 0.25, p = 0.014 and r = 0.29, p = 0.010) (Table 1). This evidence concerns the gene INS and type 2 diabetes mellitus.