The data revealed that prognostic factors of severe dengue were body temperature, neutrophils, anti-DENV IgM positive, persistent vomiting, liver enlargement, laboratory finding of increasing HCT concurrent with a rapid decrease in platelet count, miR-122-5p, miR-1246, miR-1303, miR-574-5p, miR-30d-5p, and miR-424-5p. This evidence concerns the gene CD40LG and dengue disease.