While further investigation is needed to determine what role senescence plays in SCA7 disease progression, previous reports have indicated that an increase in cellular senescence in various renal cell types is present in a multitude of renal diseases including IgA nephropathy, AKI-to-CKD transition, diabetic nephropathy, and autosomal dominant polycystic kidney disease [27, 28]. Here, ATXN7 is linked to autosomal dominant polycystic kidney disease.