Interestingly, VMH microinjection of AICAR restored the glucagon counterregulatory response to hypoglycaemia in the diabetic BB rat, a rodent model of autoimmune type 1 diabetes that, as with its human counterpart, develops a hypoglycaemic‐specific defect in glucagon secretion shortly after it develops type 1 diabetes (Figure 1).22 Here, GCG is linked to autoimmune type 1 diabetes.