Size and weight of heart left ventricular weight↑——↓; Cardiac hypertrophy: ANP, BNP↑——↓; Cardiac fibrosis: deposition of collagen↑——↓; CTGF, MMP‐2, and MMP‐9↑——↓; TIMP‐1, −4↓——↑. This evidence concerns the gene TIMP1 and fibrosis.