However, as two studies found the age of CRC diagnosis was older in LLS patients (Pico et al. 2020b), and LLS FDRs (Win et al. 2015), than LS patients and FDRs, colonoscopy surveillance could potentially commence later, consistent with Monahan et al. recommendations for MSH6 and PMS2 pathogenic variant carriers (at 35 years) (Monahan et al. 2020). This evidence concerns the gene PMS2 and colorectal carcinoma.