The full-text of 12 remaining studies was assessed for eligibility and five studies were removed for examining a different outcome (not cancer risks) (Giri et al. 2019; Pearlman et al. 2019), different research question (cancer screening adherence and perceived cancer risks in LLS CRC cases (Katz et al. 2016), UNC5C mutations in LLS patients (Kury et al. 2014), and validation of an online questionnaire in people undergoing colonoscopy to identify individuals with higher familial and hereditary CRC risks) (Kallenberg et al. 2015). The gene discussed is UNC5C; the disease is cancer.