Monahan et al. currently recommends 2-yearly colonoscopy screening for CRC (as opposed to FIT/FOBT) for LLS individuals with unexplained MMR deficiency that do not have double somatic mutations and FDRs up to 75 years commencing at 25 years, consistent with recommendations for MLH1 and MSH2 pathogenic variant carriers (Monahan et al. 2020). The gene discussed is MSH2; the disease is colorectal carcinoma.