Interestingly, PD-L1 but not PD-L2 expression seemed to be altered by chemoradiation on CD8 cells in the tumor: while there was a trend for increased PD-L1 on tumor CD8 cells (p 0.14), it was significantly upregulated on blood CD8 cells (p 0.02; Fig. 4a). Here, CD274 is linked to neoplasm.