The associations remained directionally consistent in the sensitivity analysis based on SNPs located in the IGF-1 gene region as instrumental variables with risk of COVID-19 susceptibility (OR = 0.99, 95% CI: 0.91–1.07, p=0.777), hospitalization (OR = 0.90; 95% CI: 0.74–1.10, p=0.645), and severity (OR = 1.01; 95% CI: 0.82–1.24, p=0.415) (Table 3). This evidence concerns the gene IGF1 and COVID-19.