Genetic predisposition to higher serum E2 levels proxied by rs7173595 in the CYP19A1 gene was not associated with the risk of COVID-19 susceptibility (OR = 0.32; 95% CI, 0.06–1.80, p = 0.195), hospitalization (OR = 0.28; 95% CI: 0.01–6.46, p=0.426), and severity (OR = 0.22; 95% CI: 0.00–12.73, p=0.469) in females; similarly, the associations remained directionally consistent in males with susceptibility (OR = 0.37; 95% CI, 0.08–1.67, p = 0.195), hospitalization (OR = 0.33; 95% CI: 0.02–5.11, p=0.426), and severity (OR = 0.27; 95% CI: 0.01–9.26, p=0.469) (Table 5). The gene discussed is CYP19A1; the disease is COVID-19.