Leptin and insulin treatment of colorectal cancer (CRC) cell line (HCT-116) can elevate the expression of miR-4443, which subsequently leads to down-regulation of nuclear receptor coactivator 1 (NCOA1) and TRAF4, and ultimately hinders the invasion and proliferation of HCT-116 cells [10]. This evidence concerns the gene NCOA1 and colorectal cancer.