Finally, the use of these selective probes or deconjugases for mATG8–PE revealed that GABARAP subfamily proteins regulate the cellular degradation of amyotrophic lateral sclerosis (ALS)-linked TDP-25 (the 25-kDa C-terminal fragment of TARDBP/TDP-43) protein aggregates during aggrephagy. The gene discussed is GABARAP; the disease is amyotrophic lateral sclerosis.