Levels of neutrophil S100A8/A9 (S100 calcium‐binding proteins A8/A9), involved in neutrophil aggregation and chemokine production, were also elevated in patients with T2D in a hyperglycemic state, suggesting that this mechanism may also contribute to the development of thrombinflammation.26, 27. This evidence concerns the gene IGKV1D-22 and type 2 diabetes mellitus.