On the other hand, in domain 4, we observed upregulation of KRT8, AQP3, KLHDC7B and CDH1, which tend to exhibit stronger tumor progression and metastasis, and high expression of genes NUPR1 and DBI associated with chemotherapy resistance (Figure 4H and Supplementary Figure 17D) (43,44). This evidence concerns the gene KRT8 and neoplasm.