On the other hand, in domain 4, we observed upregulation of KRT8, AQP3, KLHDC7B and CDH1, which tend to exhibit stronger tumor progression and metastasis, and high expression of genes NUPR1 and DBI associated with chemotherapy resistance (Figure 4H and Supplementary Figure 17D) (43,44). Here, AQP3 is linked to neoplasm.