Recent research trends from 2019 to 2022 included (1) IgG4-related disease, aerophagia, and early allograft injury; (2) the symptom index and exhaled nitric oxide; (3) biliary reflux; (4) adverse cardiovascular event; (5) Gaviscon double action; (6) hyaluronic acid; (7) antioxidant status; (8) acid-sensing ion channel 1a; (9) apyrimidinic endonuclease I and IL-6;. This evidence concerns the gene IL6 and immunoglobulin G4-related sclerosing disease.