Interestingly, the results showed the direct pathways that correlated with the six genes, namely, the HIF-1 signaling pathway, pathways in cancer, metabolic pathways, WNT signaling pathway, JAK-STAT signaling pathway, and p53 signaling pathway (Supplementary Figure S5), revealing that the six genes played an important role in HCC (Supplementary Figure S5). This evidence concerns the gene HIF1A and cancer.