TP53 and hepatocellular carcinoma: Interestingly, the results showed the direct pathways that correlated with the six genes, namely, the HIF-1 signaling pathway, pathways in cancer, metabolic pathways, WNT signaling pathway, JAK-STAT signaling pathway, and p53 signaling pathway (Supplementary Figure S5), revealing that the six genes played an important role in HCC (Supplementary Figure S5).