Among the six metabolic genes, ADPGK is an ADP-dependent glucokinase and catalyzes ADP-dependent phosphorylation of glucose, which is involved in gluconeogenesis/glycolysis in cancer progression and is upregulated in HCC tumor tissues (Ronimus and Morgan, 2004; Jing et al., 2020) (Supplementary Figure S4A). The gene discussed is ADPGK; the disease is hepatocellular carcinoma.