DOCK2 promotes pleural fibrosis by regulating the mesothelial to mesenchymal transition (MesoMT) leading to restrictive lung disease, as well as mediating the transition of fibroblasts to myofibroblasts (FMT) during the development of idiopathic pulmonary fibrosis (IPF) (Qian et al., 2022a; Guo et al., 2022). The gene discussed is DOCK2; the disease is pulmonary fibrosis.