The CFUs in the liver, mesenteric lymph nodes, and spleen of DOCK2−/−mice were also significantly higher than those of WT mice in the late stage of infection, suggesting that Citrobacter has spread from the mucosal layer into the bloodstream, further leading to systemic dissemination of these bacteria in DOCK2−/−mice (Liu et al., 2016). The gene discussed is DOCK2; the disease is infection.