In a Syrian hamster model of SARS-CoV-2 infection, inhibition of DOCK2 expression with CPYPP resulted in worsening of pneumonia characterized by weight loss, pulmonary edema, increased viral load, impaired macrophage recruitment, and dysregulation of the type I IFNs response (Namkoong et al., 2022). The gene discussed is DOCK2; the disease is susceptibility to pneumonia measurement.