In another disease-relevant example, the antisense transcript FOXP4-AS1 (forkhead box P4 antisense 1) suppressed ZC3H12D (zinc finger ccch domain-containing protein 12D) expression by facilitating EZH2 recruitment and subsequent deposition of repressive H3K27me3 marks, thus promoting the progression of hepatocellular carcinoma (HCC) (Ye et al., 2021). This evidence concerns the gene ZC3H12D and hepatocellular carcinoma.