EZH2 and hepatocellular carcinoma: In another disease-relevant example, the antisense transcript FOXP4-AS1 (forkhead box P4 antisense 1) suppressed ZC3H12D (zinc finger ccch domain-containing protein 12D) expression by facilitating EZH2 recruitment and subsequent deposition of repressive H3K27me3 marks, thus promoting the progression of hepatocellular carcinoma (HCC) (Ye et al., 2021).