We found that the three genes negatively associated with cuproptosis (CDKN2A, MTF1 and GLS) were risk factors for HCC overall survival (OS) (HR < 1, univariate Cox test), and most of the genes positively associated with cuproptosis were favorable factors (HR < 1, univariate Cox test), which indicated that HCC patients may benefit from cuproptosis. Here, MTF1 is linked to hepatocellular carcinoma.