T2DM is characterized by inadequate pancreatic insulin production and insulin resistance in peripheral tissues (Chatterjee et al., 2017), and diabetes-related chronic hyperglycemia can result in long-term damage to and the failure of vital organs, such as eyes, kidneys, nerves, and heart (Dodds, 2017; Park et al., 2019). Here, INS is linked to type 2 diabetes mellitus.