Davieset al. found a positive correlation between RA disease activity and soluble vascular adhesion molecule-1 (sVCAM-1), and associated it with the role of IL-6 in mediating atherosclerosis in RA.88 They went on to conclude that IL-6 trans-signaling plays an important role in vascular dysfunction in RA and blocking this pathway may be useful for RA patients. The gene discussed is IL6; the disease is atherosclerosis.