TNFRSF11B and atherosclerosis: However, there was no significant association between collagen markers ofongoing bone turnover and IMT, suggesting that bone turnover and atherosclerosis may have different pathogenic mechanisms in the setting of RA.96 Beyazalet al. also found higher OPG levels in RA patients than controls and concluded that OPG may be a useful marker to assess CV risk in RA patients.97 More studies investigating this topic area may be beneficial to clarify whether bone turnover truly plays a role in premature atherosclerosis in RA.