TNF and cancer: In one study, a water JCo extract inactivated the PI3K–Akt pathway in cancer cells (Raasmaja et al., 2019), and our data revealed that JCo extract suppressed NFκB expression and the downstream expression of chemokines and cytokines such as TNF‐α, IL‐1β, IL‐6, and CCL2 in the rat renal cell line NRK‐52E.