The results of the PPI network revealed that the core targets of Chaenomeles Fructus in the treatment of RA are TNF, IL6, IL1B, VEGFA, MAPK3, etc. TNF, IL‐6, and IL‐1B, as proinflammatory cytokines, can stimulate the inflammation and degradation of bone and cartilage and gradually lead to arthritis damage and deformity in RA patients and finally disability (Luo et al., 2022). Here, MAPK3 is linked to arthritic joint disease.