The increase in the content of cAMP and the activation of PKA eventually cause the activation of NF‐κB and the increase in the expression of the proinflammatory cytokine IL‐6, which are thought to be associated with RA disease progression (Ilchovska & Barrow, 2021; Narasimamurthy et al., 2012; Wu et al., 2013). The gene discussed is NFKB1; the disease is rheumatoid arthritis.