ACE and fetal growth restriction: A similar model that induces IUGR by removing the majority of the uterine caruncles in the sheep also found no difference in fetal blood pressure under baseline conditions; however, there was a greater hypotensive effect in IUGR fetuses following administration of phentolamine, an α-adrenergic antagonist, and captopril, an angiotensin-converting enzyme inhibitor (Edwards et al., 1999; Danielson et al., 2005).