Particularly, the Notch2 gene encoding a Notch receptor in pre-granulosa cells orchestrates cyst breakdown, postnatal apoptosis of oocytes and primordial follicles assembly (Xu and Gridley, 2013) and the oocyte-specific secretory proteins Jagged1 (a Notch ligand), Gdf9 and Bmp15 activate the Notch signaling pathway in pre-granulosa cells (Zhao et al., 2016). The gene discussed is GDF9; the disease is cyst.