Factors such as COMMD4 expression (p < 0.001), histology (astrocytoma, oligodendroglioma, Glioblastoma) (p < 0.05), grade (WHO grade) (p < 0.001), chemotherapy (p < 0.001), IDH mutation (p < 0.001) and 1p19qcodeletion (p < 0.001) (Figures 1C,E) were determined premised on the univariate analysis. This evidence concerns the gene IDH2 and glioblastoma.