The decisive factor of renal failure, traditional Chinese medicine (curcumin, rhubarb, etc.,) and herbal preparations (Shenqi pills, Huangqi-Danshen decoction, etc.,) can effectively slow down the process of renal fibrosis by regulating TGF-β/Smad, downstream signaling pathways, and Notch 1/jagged 1 (Chen et al., 2017; Liu et al., 2019). Here, NOTCH1 is linked to renal fibrosis.