IFNG and systemic lupus erythematosus: For example, a previous study showed that IFN-γ-responsive genes were significantly upregulated in SLE patients with untreated active disease relative to HCs, but there was no significant difference in a comparison of HCs with SLE patients who had stable disease due to treatment with GCs, hydroxychloroquine, and/or immunosuppressants (Dufour et al., 2018).