Most available antiarrhythmics that target Nav1.5 block the central pore (peak) INa to attenuate channel activity and thereby suppress GoF arrhythmias (Antzelevitch et al., 2007; Holmes et al., 2009; Antzelevitch, 2013; Potet et al., 2015). This evidence concerns the gene SCN5A and Arrhythmia.