The pathogenesis of AD includes the accumulation of amyloid- β (Aβ) protein in the form of extracellular senile plaques and intracellular neurofibrillary tangles formed by tau protein fibrils causing synaptic loss and neurodegeneration which leads to memory impairment and other cognitive problems (Weiner et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.