Mineralocorticoid receptor antagonist (MRA) can block sodium reabsorption and overactivation of mineralocorticoid receptor (MR) in renal epithelial or vascular tissues mediated by MR, avoiding MR overactivation leading to fibrosis and inflammation and thus protecting the function of the kidney, which has a good prognosis for patients with chronic kidney disease (Oka et al., 2022). The gene discussed is NR3C2; the disease is chronic kidney disease.