There is a complex regulation of the EMT and EndMT processes, and renal fibrosis is the result of the action of multiple signaling pathways and corresponding cytokines, such as the transforming growth factor-β (TGF-β), MAPK, Gh, Wnt, Notch, and Hedgehog signaling pathways (Zhang et al., 2022). The gene discussed is TGFB1; the disease is renal fibrosis.