In contrast to this finding, downregulation of DDR2 expression with AON in a mouse model of Alport syndrome did not decrease proteinuria, inflammation or fibrosis (Sannomiya et al., 2021), despite lowering the levels of MCP-1 and collagen I. It is not clear whether lack of overall beneficial effects are due to incomplete depletion of DDR2 or whether DDR2 does not play a role in the kidney injury in this animal model. This evidence concerns the gene DDR2 and Alport syndrome.