PPI network analysis predicts that 15 targets including ALB, EGFR, TNF, MMP9, ESR1, STAT3, APP, MMP2, HSP90AA1, HRAS, MAPK14, TLR4, KDR, MAPK8, CYP19A1 are key targets for SCPE in the treatment of AD. This evidence concerns the gene MAPK8 and Alzheimer disease.