Lei Shen and his coworkers showed that DAP had reduced endotoxin lethality in a mouse model of LPS-induced endotoxemia and suppressed the inflammatory response to LPS in Raw264.7 cells by inhibiting ROS generation, JAK1 and JAK2, and enhancing suppression of STAT1 and STAT3 phosphorylation, and ultimately prevented the STAT1 and STAT3 transport in the nucleus (Shen et al., 2017). The gene discussed is STAT3; the disease is serum lipopolysaccharide activity.