FOS and colon adenocarcinoma: The expression of c-Fos in COAD patients correlates with the occurrence of metastasis and clinical stage, and the specific molecular mechanism may be related to c-Fos upregulating the expression of genes related to epithelial mesenchymal transition, thus c-Fos may be a therapeutic target for patients with metastatic COAD (Ding et al., 2020).