FRAS1/FREM are also found to be involved in the progression of several cancers, such as lung cancer (Zhan et al., 2014), gastric cancer (Umeda et al., 2020), breast carcinoma (Li H. N. et al., 2020) and isocitrate dehydrogenase (IDH)- wild-type glioblastoma (Jovcevska et al., 2019). This evidence concerns the gene FRAS1 and cancer.