Also, some individual pyroptosis genes have been studied, such as NOD2 in colorectal cancer (Couturier-Maillard et al., 2013; Branquinho et al., 2016), gasdermin B (GSDMB) in digestive system (Zhou et al., 2020), and Gasdermin D (GSDMD) in gastric cancer (Wang et al., 2018b). Here, GSDMD is linked to colorectal cancer.