RB1 and colorectal cancer: The above results tentatively confirmed that ginsenoside CK, the intestinal flora transformant of Rb1, had significant anti-gastric cancer activity but Rb1 showed no any effects, which was similar to the results of Rb1 and CK in colorectal cancer assays (Wang et al., 2012).Network pharmacology was a new discipline based on the theory of systems biology, which analyzed the network of biological systems and selected specific signal nodes for multi-target drug molecular design (Zhang et al., 2019; Wang et al., 2021).