CD4 and autoimmune myocarditis: Although it is strongly suggested that both CD4+ and CD8+ T cells may mediate autoimmune myocarditis with overlapping and differential perspectives, there are many cell types and processes within this pathway, including the exact effects of ICIs, whose significance in the development and progression of disease are poorly determined (Bracamonte-Baran and Cihakova, 2017; Postow et al., 2018; Palaskas et al., 2020).