For example, the interaction between the breast cancer Susceptibility 1 (BRCA1) protein and the DNA damage repair protein (PALB2) is mediated by associations in predicted helical coiled-coil regions, and these two proteins mediate the homodimer of PALB2 through antiparallel coiled-coil interactions (Song et al., 2018); The four zinc-finger motifs in the coiled-coil domain of TRIM29 are also involved in the formation of homodimers and heterodimers associated with DNA binding (Hsu et al., 2021). This evidence concerns the gene PALB2 and cancer.