These above studies have shown that TRIMs can promote tumor proliferation; however, a small number of studies have revealed that some TRIMs act as tumor suppressors, such as Rong W and others have shown that TRIM35 inhibits the proliferation of breast cancer by enhancing the ubiquitination of PDK1 and inactivating AKT signaling pathway (Wang R. et al., 2022). This evidence concerns the gene AKT1 and breast carcinoma.