TRIM14 can accelerate the progression of the cell cycle by activating the Akt signaling pathway (Xu et al., 2017; Diao et al., 2020); TRIM47 levels were significantly upregulated in breast cancer tissues and cells, and TRIM47 knockdown significantly inhibited cell proliferation, migration, and invasion by suppressing the PI3K/Akt pathway (Wang Y. et al., 2020). This evidence concerns the gene AKT1 and breast cancer.