TP53 and clear cell renal carcinoma: TRIM8 was expressed at low levels in renal clear cell carcinoma with drug resistance and wild-type p53 expression, and re-expressing TRIM8 restored chemotherapeutic sensitivity to the p53 signaling pathway and reactivated it (Caratozzolo et al., 2014), suggesting that inhibiting TRIM8 expression may inhibit p53 activity in renal clear cell carcinoma.