PML and neoplasm: Additionally, PML can also interact with SPLoo, CBP, and Daxx to form PML nuclear bodies (PML-NBs), which are nonmembrane binding domains in the nucleus that regulate transcription, the antiviral response, DNA repair, apoptosis, and tumor inhibition (Zhong et al., 2000; Lindsay et al., 2008; St-Germain et al., 2008).