SMAD2 and urinary bladder cancer: In addition, TRIM59 can suppress the invasion, migration, and EMT process in bladder cancer by inhibiting the TGF-β/Smad2/3 signaling pathway (Chen et al., 2017); TRIM67 promotes the proliferation, migration, and invasion of NSCLC by positively regulating the Notch pathway (Jiang J. et al., 2020); and TRIM66 knockout inhibits the proliferation, migration, and invasion of colorectal cancer cells by inactivating the JAK2/STAT3 pathway (He et al., 2019).