In addition, TRIM46 can inducing the ubiquitination of PPAR to activate the NF-κB signaling pathway, increasing cell viability and inhibiting the apoptosis of osteosarcoma cells, so TRIM46 is considered a potential oncomarker of osteosarcoma (Jiang et al., 2020). The gene discussed is NFKB1; the disease is osteosarcoma.