RIPK1 and ischemic stroke: In RIP1 kinase death mutant mice, middle cerebral artery occlusion/reperfusion (MCAO/R) reduced infarct size and improved neurological function, and the mice also showed less inflammatory response in the infarct area, suggesting that necrotizing apoptosis and its concomitant inflammatory response can lead to acute injury after ischemic stroke (Zhang et al., 2020).