Based on the results of transcriptomics, the pathogenesis of diabetic kidney disease may involve 11 candidate differential genes: Egr1, Foxo3, Pik3r3, Fgf1, Sost, Wnt10a, Tgif2, Akt2, Mep1b, Col1a1, Apoe. The gene discussed is PIK3R3; the disease is diabetic kidney disease.