Based on the results of biochemical indicators and metabolomics, we speculated that long-term high blood glucose levels in vivo would affect the expression of oxidative kinases and protein kinases in vivo, thereby modulating the expression of growth and transformation factors, leading to abnormal levels of biochemical indicators, and at the same time causing chronic inflammation and metabolic disorders, such as arachidonic acid and fatty acid metabolic disorders. This evidence concerns the gene WEE1 and metabolic disease.