TNFSF10 and neoplasm: In addition, citrus lemon exosomes have also been shown to inhibit different tumor cell lines by specifically reaching the tumor site and activating TRAIL-mediated apoptotic cell death: A549 (human lung cancer cell line), SW480 (human colorectal adenocarcinoma) cell line), LAMA84 (chronic myeloid leukemia cell line) cancer cell proliferation (Raimondo et al., 2015).