,16 In particular, T-cell–containing tumors show expression of immunosuppressive molecules, such as programmed death-ligand 1, galectin 3, indoleamine 2,3-dioxygenase-1, and lymphocyte activating 3.17, 18, 19, 20 Although most tumors show some degree of immune infiltration, this is particularly pronounced in the most malignant tumors, that is, those that have lost 1 chromosome 3 and lack expression of BRCA1-associated protein 1 (BAP1).12 This evidence concerns the gene BAP1 and cancer.