,47 Animal studies using an AD model mouse have reported that depositions of amyloid-β and phosphorylated tau protein were found in the inner retina, especially in the retinal ganglion cell layers,5, 6, 7, 8, 9 and postmortem human brain studies also found these neurodegenerative changes in the inner retina.10 The gene discussed is MAPT; the disease is Alzheimer disease.