,4 Several neuropathological studies of individuals with Alzheimer’s disease (AD) and AD model mice have revealed the accumulation of amyloid-β or tau protein in these inner retinal layers.5, 6, 7, 8, 9, 10, 11 Clinical and population-based studies12,13 have reported that the thinning of these inner retinal layers is associated with a higher likelihood of prevalent dementia or AD.14, 15, 16, 17, 18 However, no population-based, cross-sectional study has examined the association between inner retinal thickness and subtypes of dementia. This evidence concerns the gene MAPT and Alzheimer disease.