Cell surface CRT is considered an “eat-me” signal that contributes to the phagocytic uptake of cancer cells and dying cells by the immune system [3, 15, 17, 18], which is recognized by phagocyte CD91 (CRT receptor) and mediates phagocyte recognition and clearance of apoptotic tumor cells [19–22]. The gene discussed is CALR; the disease is neoplasm.