TREM1 and neoplasm: Next, we utilized the single-cell RNA-seq data from adult and pediatric glioblastomas presented in the single-cell portal of the Broad Institute of MIT and Harvard (GEO: GSE131928),33 and confirmed TREM1 expression in both infiltrated Mφ and tumor cells that imply intercellular gene-transfer between infiltrated myeloid-derived and tumor cells in the glioblastoma microenvironment (Figure 1D).