HMGB1 and glioblastoma: According to several manuscripts, TREM1-ligand-dependent multimerization and activation are essential for directional migration of circulating myeloid-derived cells, production of the pro-inflammatory cytokines and fusogenic proteins.2,9,24,48 We found a significant reduction in the expression of HMGB1, ACTB, CIRPB, and PGLYRP1 transcripts, encoding the major TREM1 ligands, after glioblastoma-neurosphere treatment with SRI42127.