SPP1 and neoplasm: Moreover, the transcriptional levels of CXCL2, CXCL3, SPP1 cytokines were also significantly reduced, in agreement with previous observations.27 A map of tumor-host interactions in glioma at the single-cell resolution analysis predicted several ligand-receptor cross-talks between myeloid-derived and glioblastoma cells49; our results suggest that the TREM1- and HuR-dependent cell-signaling pathways are the main orchestrators of these events.