For example, feeding SPD reduced myocardial hypertrophy and improved cardiomyocyte elasticity in aged mice via enhancing arterial expression of autophagy markers (8); significantly decreased infarct size and alleviated myocardial hypertrophy in SD rats by increasing autophagic flux (9); alleviated atherosclerosis by reducing epithelial fat accumulation in APOE model mice (10); and downregulated endoplasmic reticulum stress signaling components in mice with kidney injury (11). Here, APOE is linked to atherosclerosis.