INS and colorectal cancer: In the first 20 enriched KEGG pathways of differentially methylated mRNAs between DOK and HOEC cells, 5 pathways were also enriched between SCC-9 and HOEC cells, including phosphatidylinositol signaling system, pancreatic cancer, insulin signaling pathway, colorectal cancer and adherens junction (Figures 3C, D).